Your dose of ibuprofen doesn’t completely alleviate your joint pain, so you take a couple of acetaminophen tablets for added relief. Or, maybe ibuprofen is working well for your aching joints, but you come down with a cold and take an over-the-counter (OTC) cold medicine for your cough and sore throat. Ibuprofen is an medicine used to manage mild to moderate pain, fever, inflammation, menstrual cramps, and types of arthritis. Common side effects are drowsiness, nausea, diarrhea, constipation, and ringing in the ears. Ibuprofen is an NSAID, which can cause stomach ulcers in some people. It also interacts with many other drugs. Ibuprofen drugs (like Advil) are part of the anti-inflammatory drug family known as NSAIDs, which can cause tears in the stomach lining if taken on an empty stomach. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). This medication is designed to relieve pain, swelling, and fever. It’s sold under a variety of brand names, such as Advil, Midol, and. Why is the combination safe? Acetaminophen and ibuprofen work differently and they’re cleared from the body by different organs. Acetaminophen can put some stress on the liver, and ibuprofen may put some stress on the stomach and kidneys, but if you’re using these drugs in safe amounts, there is minimal concern here. Paracetamol, also known as acetaminophen and APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief. There is mixed evidence for its use to relieve fever in children. Excedrin contains a combination of acetaminophen, aspirin, and caffeine. Acetaminophen is a pain reliever and a fever reducer. Aspirin is in a group of drugs called salicylates. Tylenol (acetaminophen) and Motrin (ibuprofen) are pain relievers and fever reducers used for treating pain and fever associated with many conditions. Motrin is also used to treat inflammatory conditions such as arthritis. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) indicated for Acetaminophen belongs to a class of drugs called analgesics. Ibuprofen belongs to the drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). Acetaminophen is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds and fevers. Includes acetaminophen side effects, interactions and indications.